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Hana Holubec Selected Research

Deoxycholic Acid (Sodium Deoxycholate)

8/2011Carcinogenicity of deoxycholate, a secondary bile acid.
1/2011Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis.
1/2009Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis.
3/2007Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles.
5/2004A proteomic study of resistance to deoxycholate-induced apoptosis.
1/2003Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas.
6/2002Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients.

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Hana Holubec Research Topics

Disease

13Neoplasms (Cancer)
08/2011 - 06/2002
8Colonic Neoplasms (Colon Cancer)
08/2011 - 01/2003
8Carcinogenesis
01/2011 - 09/2005
8Necrotizing Enterocolitis
11/2006 - 01/2002
5Adenocarcinoma
01/2011 - 01/2003
3Barrett Esophagus (Barrett's Esophagus)
02/2009 - 03/2004
3Asphyxia (Suffocation)
11/2006 - 06/2002
2Inflammation (Inflammations)
03/2007 - 04/2006
1Adenomatous Polyps
01/2011
1Polyps
01/2011
1Adenoma (Adenomas)
05/2010
1Genomic Instability
01/2010
1Aneuploidy (Aneuploid)
01/2010
1Papilloma (Papillomatosis)
09/2007
1Colitis
03/2007
1Aberrant Crypt Foci
06/2002
1Disease Progression
06/2002

Drug/Important Bio-Agent (IBA)

10Bile Acids and Salts (Bile Acids)IBA
08/2011 - 01/2003
7Deoxycholic Acid (Sodium Deoxycholate)IBA
08/2011 - 06/2002
5Proteins (Proteins, Gene)FDA Link
01/2011 - 09/2005
5Epidermal Growth Factor (EGF)IBA
11/2006 - 01/2002
3DNA (Deoxyribonucleic Acid)IBA
03/2007 - 01/2003
3Biomarkers (Surrogate Marker)IBA
06/2006 - 05/2004
2AntioxidantsIBA
08/2011 - 01/2011
2CarcinogensIBA
08/2011 - 01/2003
2Interleukin-6 (Interleukin 6)IBA
09/2007 - 03/2004
2RNA (Ribonucleic Acid)IBA
03/2007 - 04/2006
2Arginine (L-Arginine)FDA Link
10/2006 - 02/2006
1Chlorogenic AcidIBA
08/2011
1Dietary Fats (Dietary Fat)IBA
08/2011
1MicroRNAs (MicroRNA)IBA
01/2011
1SERPIN-B5 (maspin)IBA
01/2011
1MicronutrientsIBA
01/2011
1bile acid binding proteinsIBA
02/2009
1Messenger RNA (mRNA)IBA
02/2009
1Cytotoxins (Cytolysins)IBA
01/2009
1MutagensIBA
01/2009
1Sirolimus (Rapamycin)FDA Link
01/2009
1Acetates (Acetic Acid Esters)FDA Link
09/2007
1anthraceneIBA
09/2007
1Codon (Codons)IBA
09/2007
1Cre recombinaseIBA
12/2006
1PolyaminesIBA
10/2006
1Proteasome Endopeptidase Complex (Proteasome)IBA
04/2006
1UbiquitinIBA
04/2006
13-nitrotyrosineIBA
02/2006
1Drinking WaterIBA
02/2006
1A-factor (Streptomyces)IBA
09/2005
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
09/2005
1Apoptosis Regulatory ProteinsIBA
05/2004
1Interleukin-10 (Interleukin 10)IBA
03/2003
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2003
1CytokinesIBA
01/2003
1LectinsIBA
06/2002
1dolichos biflorus agglutininIBA
06/2002
1Interleukin-12 (IL 12)IBA
06/2002
1NAD (NADH)IBA
06/2002
1Interleukin-18 (Interleukin 18)IBA
06/2002

Therapy/Procedure

1Enteral Nutrition (Feeding, Tube)
06/2002